Interaction of Metal Ion Stabilized Oligomeric Dipeptide with Lipid Membrane: Concurrent Observations of Supported Lipid Membrane, Wetting, and Uptake
Year: 2025
Type: article
Abstract: The interaction of biomolecules with cell membranes is crucial due to their important role in governing cellular function and membrane dynamics. However, most of the studies predominantly focus on the interaction of monomeric forms of biomolecules with lipid membranes, leaving the effects of cytotoxic oligomeric self-aggregates largely unexplored. In this study, we report that metal ion stabilized oligomeric intermediates of diphenylalanine cause wetting and uptake, induce coalescence, resulting in significant structural alterations of lipid membranes with varying surface charges. On the other hand, fibrillar morphology of diphenylalanine facilitates the formation of supported phospholipid membranes through liposome deformation. These insights open new research directions with profound implications for biomedicine and nanotechnology and help in fundamental biological understanding.
Authors: Priyanka Nath, Debanjan Bagchi, Avijit Maity, Huma Tabassum, Suman Choudhury, Naveen Kumar, Anjan Chakraborty
Institution: Indian Institute of Technology Indore
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4410765072