Synthesis and Evaluation of Trehalose‐Based Mertansine Warheads for Bacillus Calmette–Guérin Delivery of Anticancer Agents
Year: 2025
Type: article
Abstract: Nonmuscle invasive bladder cancer (NMIBC) accounts for 75% of bladder cancer cases, with Bacillus Calmette-Guérin (BCG) immunotherapy as the gold standard for high-risk patients. BCG elicits a robust immune response but is limited by adverse effects and resistance. To enhance its efficacy, a trehalose-based conjugation strategy is developed, tethering a cytostatic agent to BCG via a cleavable disulfide linker. This system enables selective drug integration into the BCG envelope and controlled release in tumor cells, aiming to improve therapeutic precision while minimizing toxicity. This approach combines immunotherapy with targeted chemotherapy, offering a promising strategy for NMIBC treatment.
Source: ChemBioChem
Authors: Michael Grimmeisen, Xuan Wang, Melissa Weldle, Kerstin Sartory, Sara Benkhelifa, Yu Zhang, Trinh Dao, Jonas Meyer, Oliver Gorka, Olaf Groß, Claudia Jessen‐Trefzer
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,430
Funders: Innovative Research Team of High-level Local University in Shanghai, Deutsche Forschungsgemeinschaft, Albert-Ludwigs-Universität Freiburg, Université de Montpellier, Horizon 2020 Framework Programme, Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg, H2020 European Research Council, FP7 Ideas: European Research Council
Awards: G1888663043, G2234928323, G259924242, Novel small molecule activators of the NLRP3 inflammasome as immunostimulants, Zellsortiersystem, G2899880, G3079612173, G3345895242, G3523822304, G3544412130, SFB 1479: Onkogengetriebener Immun Escape (OncoEscape), G3986724495, G4145974192, G4578989300, SFB 1160: Immunpathologie aufgrund eingeschränkter Immunreaktionen (IMPATH), EXC 2189: CIBSS Centre for Integrative Biological Signalling Studies, TRR 167: Entwicklung, Funktion und Potential von myeloiden Zellen im zentralen Nervensystem (NeuroMac), G5931083012, G6000535164, G6952166915, G735672719, G7434790516, Inflammasome-induced IL-1 Secretion: Route, Mechanism, and Cell Fate, G7833425038, SFB 1425: Die heterozelluläre Natur kardialer Läsionen: Identitäten, Interaktionen, Implikationen, G8688555725, GRK 2606: Entschlüsselung zellulärer Proteasefunktionen durch Identifizierung und Analyse von Proteasesubstraten (ProtPath)
OpenAlex ID: W4410767181