The effect of uric acid-lowering therapy on vascular stiffness in patients with gout
Year: 2025
Type: article
Abstract: Several studies have reported that vascular stiffness and risk of cardiovascular disease increase in patients with gout. Although it has been reported that uric acid-lowering treatment improves vascular stiffness in several patient groups, it remains unclear whether uric acid-lowering treatment improves vascular stiffness in patients with gout. Therefore, this study aimed to determine whether vascular stiffness improves by measuring the augmentation index along with uric acid-lowering treatment for 2 years in patients with gout. This study showed that vascular stiffness improved in 67% of the patients, and patients with high initial vascular stiffness showed better improvement in vascular stiffness after uric acid-lowering treatment. Regression analysis was performed to identify factors that improved vascular stiffness; however, no factors that improved vascular stiffness were found. Among patients who had already received uric acid-lowering treatment for more than 2 years before starting augmentation index measurements, 67.7% showed improvement in vascular stiffness. Therefore, it is believed that uric acid-lowering treatment in patients with gout can improve vascular stiffness, and if uric acid-lowering treatment is continued, improvement in vascular stiffness is expected to occur gradually over a long period of time.
Authors: Wooseong Jeong, Jinseok Kim
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4410768636