Work

Room temperature, metal-free, CDI-promoted, ex-situ protocol for S-methyl thioester synthesis

Year: 2025

Type: article

Abstract: S-methyl thioesters have proven to be useful intermediates in many biosynthetic reactions and their occurrence in bioactive molecules further enhance their appeal. Shortcomings in several reported synthetic protocols have led us to disclose herewith a mild, room temperature ex situ protocol that provides access to a large number of thioesters (aryl, heteroaryl, alkyl, amino acids). Late-stage functionalization strategies were also performed on commercial pharmaceutical drugs (containing carboxylic acid functionality) while further in situ conversion to valuable compounds has also been achieved.

Source: Scientific Reports

DOI: 10.1038/s41598-025-97728-3

Authors: Manisha A. Patel, Vandana Sharma, Rupali Chavan, Juhi Pal, Santosh J. Gharpure, Anant R. Kapdi

Institutions: Institute of Chemical Technology, Indian Institute of Technology Bombay

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,690

Funders: Indian Institute of Technology Bombay, Science and Engineering Research Board