Work

Electroporation-induced nerve excitability in human brain model under pulsed electric field tumor ablation

Year: 2025

Type: article

Abstract: A mechanism model that considered the effect of electroporation (EP) current to simulate the nerve fiber excitability during pulsed electric field tumor ablation in the human brain was developed for the first time. The results show that the EP current reduces the time to peak depolarization by about 49 μs and the peak value by about 442.9 mV for nerve fibers nodes located 0.5 cm under the tumor after applying 100 μ s monopolar pulse. In addition, when a 7 V monopolar pulse was applied after EP occurred, the action potentials (APs) were generated or not in the model without or with EP current, respectively. Finally, compared with the simple ellipsoidal brain model in our previous study, the same optimal voltage of 3100 V for bipolar pulses to cover the tumor was obtained in both models, and the ablation volumes including healthy tissues in the human brain model was reduced by 0.41 c m 3 when applying the bipolar pulses. The proposed model can reflect the nerve excitability with the realistic brain tissues more accurately than the previous ellipsoidal model, and the simulation results have great significance in pulsed electric field tumor ablation applications.

Source: Materials & Design

DOI: 10.1016/j.matdes.2025.114129

Authors: Fei Guo, Weina Zhou, Cong Zou, Li Luo

Institution: Chongqing University of Posts and Telecommunications

Language: English

Topic: Microbial Inactivation Methods

Subfield: Biotechnology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,650