Work

Chemodivergent C-to-N atom swap from benzofurans to benzisoxazoles and benzoxazoles

Year: 2025

Type: article

Abstract: We present a chemodivergent net C-to-N atom swap in benzofurans, affording benzoxazoles or benzisoxazoles via photo-mediated oxidative benzofuran cleavage, followed by oxime or imine formation, and cyclization using commercially available reagents.

Source: Chemical Science

DOI: 10.1039/d5sc02032h

Authors: Ann-Sophie K. Paschke, Stefanie Schiele, Camille Pinard, Filippo Sandrini, Bill Morandi

Institutions: ETH Zurich, Laboratory of Organic Chemistry

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: National Science Foundation, Fonds der Chemischen Industrie, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Eidgenössische Technische Hochschule Zürich

Awards: Diffractometer with rotating anode, G298171496, New Synthetic Methods for C–N bond formation