Dihydropyrimidinone Based Chromones as New α‐Glucosidase Inhibitors
Year: 2025
Type: article
Abstract: This study assesses newly synthesized chromones with a 3,4‐dihydropyrimidin‐2(1H)‐one core at C‐3, combined with triazole derivatives for their antidiabetic potential. Compounds 5a and 5b showed strong inhibition of α‐glucosidase, with IC 50 values of 58.99 ± 4.15 nmol and 49.18 ± 2.18 nmol. Docking studies indicated effective binding within the active site of α‐glucosidase (−10.7 kcal/mol for 5a and −10.9 kcal/mol for 5b). Computational assessments suggested both compounds have favorable profiles for drug‐likeness, ADME, and toxicity, highlighting their potential as therapeutic agents for diabetes.
Source: ChemistrySelect
Authors: Kumara Swamy Taviti, T. B. Patrudu, Vishnuvardhana Kishore Polisetti, Venkatesh Bhumireddy Chinnachennaiahgari, Satyanarayana Yatam, Naresh Kumar Katari, Rambabu Gundla
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,880
OpenAlex ID: W4410804763