Knockdown of PARM1 Alleviates Aortic Valve Calcification via the PRKCH-MAPK Signaling Pathway
Year: 2025
Type: article
Abstract: With the aging of the population, the prevalence of calcific aortic valve disease (CAVD) has increased yearly. However, effective means to delay or even reverse the progression of CAVD are still lacking. This study revealed that prostate androgen-regulated mucin-like protein 1 (PARM1) expression was significantly up-regulated in calcified aortic valve tissues. Functional investigations demonstrated that PARM1 knockdown effectively suppressed osteogenic differentiation of valvular interstitial cells (VICs) and mitigated pathological aortic valve calcification. Mechanically, PARM1 knockdown down-regulated PRKCH mRNA expression, consequently attenuating MAPK pathway activation during the osteogenic differentiation of VICs. In conclusion, PARM1 could be a feasible target for CAVD prevention.
Authors: Haochang Hu, Xian Zhu, Jinyong Chen, Naifang Cao, Shuangshuang Yang, Lan Xie, Wangxing Hu, Si Cheng, Juan Fang, Yi Qian, Dilin Xu, Ningjing Qian, Dao Zhou, Jin Lu, Hanyi Dai, Junhui Xue, Wei Zhu, Jian’an Wang, Xianbao Liu
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,750
OpenAlex ID: W4410806417