Work

Numerical study on the biomechanics mechanism of Type II endoleak after EVAR for Abdominal Aortic Aneurysm

Year: 2025

Type: article

Abstract: Type II endoleak, a common complication following Endovascular Aneurysm Repair (EVAR), remains a leading cause of re-intervention, yet its biomechanical mechanisms are not fully understood. This study employed an idealized model of the aneurysmal sac, Inferior Mesenteric Artery (IMA), and Lumbar Arteries (LAs) to explore endoleak mechanisms using Computational Fluid Dynamics (CFD) and Fluid-structure Interaction (FSI) simulations. The results demonstrated that pressure differences between the sac and branch arteries drive Type II endoleak, with the IMA often serving as the primary inlet. Under the influence of Type II endoleak, flow disturbances near the IMA and LAs suggest potential challenges in thrombus formation. Comparative analysis between CFD and FSI showed that CFD overestimated peak flow velocity in the IMA and underestimated sac pressure, while also displaying a temporal lag in velocity and pressure curve throughout the cardiac cycle. These findings indicate that CFD is suitable for rapid assessments where precision is less critical, whereas FSI is more appropriate for detailed mechanistic studies. This work clarifies the biomechanics of Type II endoleak and underscores the importance of selecting appropriate numerical methods in clinical and research contexts.

Source: PLoS ONE

DOI: 10.1371/journal.pone.0323358

Authors: Xiao Mo, Feng Zhang, Kai-Xiong Qing, Yang Xiao

Institutions: Kunming University of Science and Technology, Kunming Medical University, First Affiliated Hospital of Kunming Medical University

Language: English

Topic: Aortic aneurysm repair treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,382