Methylation risk score of C-reactive protein associates sleep health with related health outcomes
Year: 2025
Type: article
Abstract: C-reactive protein (CRP) reflects inflammation status and is linked to poor sleep, metabolic and cardiovascular health. Methylation (MRS) and polygenic risk scores (PRS) reflect long-term systemic inflammation, and genetically-determined CRP, respectively. To refine understanding of inflammation-linked sleep and health outcomes, we construct PRS-CRPs using GWAS summary statistics and a previously-developed MRS-CRP in the Hispanic Community Health Study/Study of Latinos. Via survey-weighted linear regression, we estimate associations between blood-, PRS-, and MRS-CRP, with multiple sleep and health outcomes (n = 2217). MRS-CRP and PRS-CRPs are associated with increasing blood-CRP level by 43% and 23% per standard deviation. MRS-CRP is associated with obstructive sleep apnea (OSA) traits, long sleep duration, diabetes and hypertension, while PRS-CRPs were not. Blood-CRP level is associated with sleep duration and diabetes. Adjusting for MRS-CRP weakens OSA-diabetes/hypertension associations. Consequently, MRS-CRP is a stronger marker than blood-CRP and PRS-CRP to systemic inflammation associated with poor sleep and related comorbidities.
Source: Communications Biology
Institutions: Beth Israel Deaconess Medical Center, Harvard University, Brigham and Women's Hospital, Emory University, National Institute on Aging, The Lundquist Institute, Harbor–UCLA Medical Center, University of Virginia, University of California, Los Angeles, Northwestern University, University of Miami, University of Vermont, University of California San Diego, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Albert Einstein College of Medicine
Language: English
Topic: Sleep and related disorders
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $4,190
Funders: U.S. Department of Health and Human Services, Office of Dietary Supplements, University of Miami, Northwestern University, San Diego State University, National Institutes of Health, University of Illinois at Urbana-Champaign, Gillings School of Public Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities
Awards: G1081972346, G1083745640, G109384441, G1129490614, G1140476625, Multi-Ethnic Study of Atherosclerosis (MESA) Study, G122677224, G1261793039, MESA, G1276754516, G1312369436, G1327559120, G1409423729, Hispanic Community Health Study, G1455175283, Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA), G152041249, G1609525565, G1640378483, G1666450717, G1686417863, UCLA Clinical and Translational Science Institute, G1818487580, G1845395357, G1866572497, G1982334678, G1984718218, Large Scale Sequencing and Analysis of Genomes, G2130630498, G2144938473, G22458031, G2262782284, MESA, G2466919156, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, G2494211023, G2528054427, G2553282249, MESA Family Study, G2585438117, G2644289446, G2651066328, G2655143993, G2663518188, G2733059257, MESA, G2828204922, G2837638605, G286372155, G2905571579, G290884426, G291913881, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING, G2970637568, G297113894, G3093995152, G3256118428, G33312777, Hispanic Community Health Study, G343705321, G3614733703, G3647016462, G3687594596, G370977179, G3722034730, G3809606526, MESA, G3919367648, G3990748671, G399481048, Rare variants and NHLBI traits in deeply phenotyped cohorts, G4196558080, G4222455271, G4296038422, TITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA), G432753757, Hispanic Community Health Study, G4512137732, OPTION 3. 4/1/2014 - 3/31/2015. MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) - READING CENTER, NHLBI, MESA Family Study, MESA, G50080621, G5015503974, MESA Family Study, G5088122703, G5102588038, G5108002584, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-ULTRASOUND, G5234713383, G5254636657, G528357465, G5365244667, HISPANIC COMMUNITY HEALTH STUDY - COORDINATING CENTER, G543802643, G548714024, G562502316, G5654179670, G5785169696, G5787256936, G5871482443, G596642789, G6075306088, G6088185517, G6095866717, G6149955053, G6202424770, G6290268315, G6359107525, G639301372, G6405494218, Institute for Clinical and Translational Research, MESA, G646921540, G6514094751, G66341962, G6742279884, G7132511053, MESA, G7399262704, G7667010295, G78770644, Clinical and Translational Science Award, G820454163, Studies of Rare Genetic Variation in the Isolated Population of Sardinia, G8852914737, G8932431361, G8987601928, G9000004549, G9000004784, G9000006353, G9000017360, G9000019818, G9000020291, G9000025517, G9000038858, G9000063950, G9000065698, G9000114775, G9000199330, Diabetes Research Center (DRC), Leveraging omics data to understand sleep health and its consequences among diverse Hispanics/Latinos, UCLA Clinical and Translational Science Institute, G937084196, G94668252, G991334795
OpenAlex ID: W4410811391