Work

Synthesis of Ethynyl Trifluoromethyl Sulfide and Its Application to the Synthesis of CF3S-Containing Triazoles

Year: 2025

Type: article

Abstract: The unprecedented use of ethynyl trifluoromethyl sulfide (CF3S–C≡CH) as a synthetically useful building block has been described for the first time. It was reacted with various aromatic and aliphatic azides under copper-catalyzed conditions to yield a novel class of 1,4-disubstituted triazoles bearing the SCF3 group (15 examples, up to 86% yield).

Source: Molecules

DOI: 10.3390/molecules30112358

Authors: Alejandra Riesco-Domínguez, Hussein Hammoudeh, Daniel Blanco-Ania, Floris P. J. T. Rutjes

Institution: Radboud University Nijmegen

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,258

Funder: European Commission