Exploring the Impact of Phenanthroline‐Based Glycoconjugated Ru(II) Polypyridyl Photosensitizers on Metastasis‐Related Processes
Year: 2025
Type: article
Abstract: Novel water‐soluble, phosphorescent ruthenium(II) polypyridyl‐glycoconjugates of general formula [Ru{ N ‐(1,10‐phenanthroline)} 2 { N ‐(1,10‐phenanthrolin‐5‐yl)‐β‐glycopyranosylamine}][Cl] 2 (glycopyranosyl = D‐glucopyranosyl ( 1 ), D‐mannopyranosyl ( 2 ), L‐rhamnopyranosyl ( 3 ), L‐xylopyranosyl ( 4 ), and 2,3,4‐tri‐ O ‐acetyl‐L‐xylopyranosyl ( 5 )) and corresponding aglycone [Ru{ N ‐(1,10‐phenanthroline)} 2 { N ‐(1,10‐phenanthrolin‐5‐amine)}][Cl] 2 ( 6 ) have been synthesized and fully characterized. Their stability and behavior in physiological media have been assessed using ultraviolet visible spectroscopy (UV‐Vis) and 1 H nuclear magnetic resonance (¹H‐NMR), revealing minor N ‐glycosidic cleavage and high photostability. The photocytotoxicity of the complexes has been evaluated in two different cancer (PC‐3 and MCF‐7) and one nontumorigenic (HFF‐1) cell lines. While exhibiting no toxicity in the dark, some glycoconjugates achieve photoselectivity indexes of up to 40 upon blue‐light irradiation. Remarkably, complexes 1 – 6 potently affect the metastatic phenotype of PC‐3 cells, evidenced by the inhibition of migration in the wound healing assay and the increased resistance to trypsin detachment following photoactivation.
Source: Chemistry - A European Journal
Authors: Elena de la Torre‐Rubio, María‐Selma Arias‐Pérez, Lourdes Gude, Tomás Cuenca, Cristina García‐Iriepa, Eva Royo
Institution: Universidad de Alcalá
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,640
OpenAlex ID: W4410814216