Work

An Intrauterine Case of Explosive Growth of Neurofibromatosis during Pregnancy with Fetal Death in Mid-Pregnancy: A Case Report

Year: 2025

Type: article

Abstract: Introduction: Neurofibromatosis type 1 (NF1) is one of the most prevalent autosomal dominant inherited diseases, with an incidence rate of 1/3,000. The hallmark clinical features of NF1 include coffee milk spots, multiple neurofibromas, and freckles in the armpit or groin. Numerous studies have indicated a higher incidence of pregnancy-related complications in patients with NF1, including fetal growth restriction and preeclampsia. Case Presentation: This case study describes a pregnant woman with NF1 who unfortunately experienced intrauterine fetal death during her second trimester and developed preeclampsia and HELLP syndrome. Conclusion: This case highlights the need for close monitoring and management of patients with NF1 during pregnancy and the critical role of multidisciplinary collaboration and follow-up of MDT.

Source: Case Reports in Oncology

DOI: 10.1159/000545803

Authors: Xiyan Ouyang, Yanli Li, Xin Li, Lingna Chai, Jie Shi, Han Gao

Institutions: Wuhan University of Science and Technology, Huazhong University of Science and Technology

Language: English

Topic: Neurofibromatosis and Schwannoma Cases

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,170