Year: 2014
Type: dissertation
Abstract: Cognitive and memory impairments significantly affect multiple domains in life and play major roles in disease. Identifying critical mechanisms and factors that mediate memory consolidation and enhancement may represent an important approach for increasing cognition in normal adults and preventing or treating cognitive impairments. The expression of the C/EBP- target gene insulin-like growth factor 2, (IGF-II) is required for memory consolidation; furthermore, IGF-II administration during memory consolidation produces memory enhancement, increased memory persistence and prevents forgetting. In this thesis, I investigated the therapeutic potential of IGF-II to promote memory consolidation when administered systemically. In addition, I investigated one particularly interesting and unique aspect of IGF-II, its status as an imprinted gene, as a possible mechanism for the cognitive enhancing effects of IGF-II. This knowledge is a prerequisite for developing clinical applications that aim at either enhancing cognition or preventing/reversing memory impairment.
DOI: 10.54014/0vca-4kf0
Author: Kohtz, Amy S.
Institution: University at Albany, State University of New York
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4410820004