Common Diseases Presenting in an Uncommon Way: Metastatic Small-Cell Lung Carcinoma Mimicking Merkel Cell Carcinoma
Year: 2025
Type: article
Study design: Case Report
Abstract: A 65-year-old Caucasian woman presented with a rapidly enlarging, painless forehead lesion initially presumed to be Merkel cell carcinoma (MCC). Originating as a 3 mm pink papule, the lesion expanded to over 12 mm within six months. Subsequent histopathologic and radiologic evaluation revealed it to be the initial manifestation of metastatic small-cell lung carcinoma (SCLC). Despite undergoing surgical resection under the presumption of localized MCC, advanced imaging later identified a primary pulmonary neoplasm with diffuse metastatic spread. Histologically, both MCC and SCLC are characterized by poorly differentiated neuroendocrine morphology, complicating clinical distinction. Cutaneous metastases from SCLC, although rare, can deceptively mimic primary neuroendocrine skin neoplasms, as exemplified in this case. This diagnostic pitfall underscores the imperative for comprehensive staging prior to initiating definitive therapy, as incomplete evaluation may precipitate unnecessary surgical intervention and delay optimal systemic treatment.
Source: Cureus
DOI: 10.7759/cureus.84968
Author: Alice Boican
Institutions: University of South Florida, HCA Healthcare
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4410822301