Work

Protocols of Thiamine Supplementation: Clinically Driven Rationality vs. Biological Commonsense

Year: 2025

Type: article

Abstract: Background: Thiamine deficiency requires supplementation to prevent or reverse severe clinical complications. Are supplementation protocols correctly tailored in neurology? Methods: An examination of recommended thiamine supplementation protocols is undertaken. Results: Recommended thiamine levels are much higher than required, reaching a median daily intake and total amount of 7.8-fold and 30.6-fold greater than the whole-body thiamine store, respectively. The high initial intake is often followed by tapering over days or weeks. Conclusions: Thiamine supplementation protocols in neurology mostly recommend far higher doses than those biologically required and could probably be simplified to a single 100 mg dose injected as early as possible.

Source: Journal of Clinical Medicine

DOI: 10.3390/jcm14113787

Author: Mickael Bonnan

Institutions: Centre Hospitalier Universitaire Henri-Mondor, Hôpitaux Universitaires Henri-Mondor

Language: English

Topic: Alcoholism and Thiamine Deficiency

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,137