Work

Hydrogen Bond-Controlled Site-Selective C–H Borylation at the Remote-Position of Naphthalene Derivatives

Year: 2026

Type: article

Abstract: We successfully developed site-selective C–H borylation at the remote position (6-position) of 1-substituted naphthalene derivatives, which was controlled by hydrogen bonding between the substrate-recognition site of the catalyst (hydrogen bond donor) and the functional group of the substrate (hydrogen bond acceptor). By changing the ligands, 7-position-selective remote C–H borylation of naphthalene derivatives with a functional group at the 2-position can also be achieved. These are rare examples of site-selective C–H borylation at a remote position of naphthalene derivatives.

Source: Organic Letters

DOI: 10.1021/acs.orglett.6c04275

Authors: Xu Lu, Safaa A. Abbas, Genki Yoshino, Yoichiro Kuninobu

Institutions: The University of Tokyo, Kyushu University

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: Japan Society for the Promotion of Science

Awards: G5920023898, Creation of Novel Catalysts and Development of Highly Selective C-H Transformations Focusing on Noncovalent Interactions, G6947316753, Creation of Regio- and Stereocontrol Methods of C-H Transformations