Mitochondrial DNA transfer between malignant cells and T lymphocytes shapes the cancer-immunity dialogue
Year: 2025
Type: editorial
Abstract: Nonmutated mitochondrial DNA (mtDNA) from T lymphocytes can be incorporated into cancer cells bearing mutated mtDNA to repair their bioenergetic deficiency. However, a recent paper by Ikeda et al. indicates that mutated mtDNA from malignant cells can also be transferred into tumor-infiltrating T lymphocytes to subvert their function in cancer immunosurveillance.
Source: OncoImmunology
Authors: Liwei Zhao, Peng Liu, Oliver Kepp, Guido Kroemer
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,913
Funders: Association pour la Recherche sur le Cancer, Seerave Foundation, Agence Nationale de la Recherche, Fondation pour la Recherche Médicale, Institut Universitaire de France, Institut National Du Cancer, Cancéropôle Ile de France, Ministère des Solidarités et de la Santé, HORIZON EUROPE European Innovation Council
Awards: Next-generation phenotypic screening for oncological applications, Lung cancer prevention and interception, Mitochondrial copper targeting to modulate inflammatory macrophages, Microbiota-centered interventions to solve antibiotics-induced primary resistance to immune checkpoint inhibitors, Energizing the failing heart, Université de Paris, The RUSH (retention using selective hooks) system: a chemical-genetic system for the in vivo manipulation of intercellular communication
OpenAlex ID: W4410825550