Work

Sodium/hydrogen exchanger 8 affects sheet migration of human intestinal epithelial cells (HT29MTX) by influencing the actin cytoskeletal rearrangement

Year: 2025

Type: article

Abstract: The Na+/H+ exchanger 8 (NHE8) plays an important role in the regulation of intracellular pHi, cell proliferation, and epithelial sheet migration in HT29MTX intestinal cells. NHE8 knockdown cells lack the ability to dynamically rearrange the actin cytoskeleton at the wound front, resulting in a reduced migration rate. These observations provide insights into the molecular mechanism of the downregulation of this transporter in human ulcerative colitis and its role in epithelial restitution.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00826.2024

Authors: Ju Wang, Christian Stock, Azam Salari, Ursula E. Seidler, Katerina Nikolovska

Institution: Medizinische Hochschule Hannover

Language: English

Topic: Ion Transport and Channel Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Deutsche Forschungsgemeinschaft