Work

Listeria monocytogenes Endophthalmitis—Good Outcome With Rapid Diagnosis Using MALDI‐TOF and Treatment With Benzylpenicillin and Trimethoprim–Sulfamethoxazole

Year: 2025

Type: article

Abstract: Purpose: Describe a case of rapidly diagnosed Listeria monocytogenes endophthalmitis, with a clearly established route of endogenous seeding, treated with dual antibiotics, with outcomes better than many reported. Observations: A 79‐year‐old male developed Listeria monocytogenes endophthalmitis after a gastrointestinal infection with an associated bacteraemia. Rapid microbiologic diagnosis was obtained via matrix assisted laser desorption ionization–time of flight mass spectrometry (MALDI‐TOF). The case was managed with 3 weeks of benzylpenicillin and 6 weeks of trimethoprim–sulfamethoxazole. Visual acuity in the affected eye was preserved with a mild to moderate residual deficit. Conclusion: Clinicians should be aware of the potential for Listeria monocytogenes endophthalmitis associated with preceding gastrointestinal symptoms. Better outcomes are associated with rapid diagnosis, and the use of dual antimicrobial therapy should be considered.

Source: Case Reports in Ophthalmological Medicine

DOI: 10.1155/crop/6380811

Authors: Thomas Ledger, Martin Plymoth, Mark Douglas

Institutions: The University of Sydney, Westmead Hospital, Western Sydney Local Health District, Umeå University, Westmead Institute for Medical Research

Language: English

Topic: Ocular Infections and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $790