Work

CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients

Year: 2025

Type: article

Abstract: Background This study explores the factors related to the expression levels of carbohydrate antigen 199 (CA199) and carcinoembryonic antigen (CEA) and their association with poor postoperative prognosis in patients with esophageal squamous cell carcinoma (ESCC) who underwent minimally invasive resection. Methods Eighty patients with ESCC who underwent minimally invasive surgery were divided into two groups: 40 with poor prognosis (recurrence) and 40 with good prognosis (no recurrence). Additionally, 80 healthy subjects were selected as a control group. Serum CA199 and CEA levels were measured before surgery and 3 and 6 months postoperatively. Results The serum CA199 and CEA levels in the experimental group were significantly higher than in the control group ( P < 0.05). Patients with poor prognoses within the experimental group had higher CA199 and CEA levels than those with good prognoses ( P < 0.05). In the poor prognosis group, CA199 and CEA levels at 6 months were significantly higher than at 3 months post-surgery ( P < 0.05). Conclusion Poor prognosis in ESCC patients after minimally invasive resection may be influenced by factors such as lymph node metastasis, lesion length, and tumor location. Elevated CA199 and CEA levels postoperatively can serve as predictors of poor prognosis in patients with ESCC.

Source: Open Medicine

DOI: 10.1515/med-2024-1127

Authors: Cheng Ji, Lingjia Ji, Fei Wang, Anping Zhang, Liang Shen

Institutions: Second Affiliated Hospital of Nantong University, Affiliated Hospital of Nantong University

Language: English

Topic: Esophageal Cancer Research and Treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,373