Work

Effects of Fisetin on Lipid Metabolism in Caenorhabditis elegans

Year: 2025

Type: article

Abstract: Objectives: Fisetin (3,3',4',7-tetrahydroxyflavone) is a yellow-pigmented flavanol found in strawberries, cucumbers, peaches, and honey locusts. Fisetin has been reported to have anti-cancer, anti-aging, and anti-inflammatory properties, and there was limited evidence that fisetin has anti-obesity effects. Thus, this study aimed to determine if fisetin reduces fat accumulation using Caenorhabditis elegans as an in vivo model. C. elegans is an invertebrate animal model commonly used in life science research, including the study of lipid metabolism, due to its ease of maintenance, rapid lifecycle, and highly conserved genes and pathways with mammals.

Source: Current Developments in Nutrition

Authors: Sida Li, Zixuan Teng, Nikolas J Rodriguez, Yeonhwa Park

Institution: University of Massachusetts Amherst

Language: English

Topic: Flavonoids in Medical Research

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,000

Funders: U.S. Department of Agriculture, National Institute of Food and Agriculture, Center for Agriculture, Food and the Environment, University of Massachusetts Amherst