Galactose-modified erythrocyte membrane fusion liposomes enable the targeted delivery of drug nanoparticles to the liver
Year: 2025
Type: article
Abstract: The safe and efficient delivery of chemicals and biologics remains crucial for liver disease therapy. In this study, we developed a targeted drug delivery system utilizing a galactose-modified erythrocyte membrane coating technique and drug liposome nanoparticles, which were further optimized using orthogonal experiments and response surface analysis. The specificity, precision, accuracy, and stability exhibited satisfactory performance in bioanalytical analysis. Specifically, targeting ligands (Gal-DSPE-PEG3400) were efficiently inserted into red blood cell (RBC) membranes using a facile insertion method. When Gal-DSPE-PEG3400-RBC was fused with fenofibrate liposome nanoparticles (FNB-Lip) by co-extrusion, the resulting galactose-modified erythrocyte membrane fusion liposome nanoparticles (Gal-RBC-FNB-Lip) showed long-term stability, excellent biocompatibility, prolonged retention time, and superior liver accumulation and therapeutic efficacy. These qualities make it suitable for effective drug delivery. The findings of this study will provide a fundamental basis for research and development of liver-targeted drugs and offer novel insights into the treatment of clinical liver diseases.
Source: RSC Advances
DOI: 10.1039/d4ra07489k
Authors: Jiayu Song, Huanhuan Zhang, Xiaohui Zhang, Meiying Liu, Dan Peng, Yuan Ren, Yan Sun, Yunlan Li
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,042
Funders: Shaanxi Administration of Traditional Chinese Medicine, National Natural Science Foundation of China, Shanxi Medical University, Yakult Bio-Science Foundation, Shanxi Provincial Key Research and Development Project, Henan Provincial Science and Technology Research Project, Division of Graduate Education
OpenAlex ID: W4410840347