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Two-Sample Mendelian Randomization Analysis of the Correlation Between Allergic Rhino-Conjunctivitis and Concomitant Diseases and Peripheral Blood Eosinophil Count

Year: 2025

Type: article

Abstract: To explore the causal relationship between allergic rhino-conjunctivitis, asthma, and eczema and peripheral blood eosinophil count from the perspective of single nucleotide polymorphisms through two-sample Mendelian randomization analysis. Five methods, including inverse variance weighting, MR-Egger regression, median weighting, simple model, and weighted model, were used to evaluate the relationship between allergic rhino-conjunctivitis, asthma, and eczema and peripheral blood eosinophil count. Sensitivity analysis (pleiotropy, heterogeneity, and leave-one-out test) was used to evaluate the robustness of the results. There was a significant causal association between SNPs of allergic rhinitis , allergic conjunctivitis, asthma, and eczema and SNPs of peripheral blood eosinophil count. The sensitivity analysis of SNP instrumental variables showed no significant heterogeneity or pleiotropy, indicating that the results are robust. Evidence shows that peripheral blood eosinophil count is associated with an increased risk of allergic rhino-conjunctivitis, asthma, and eczema.

Source: Advances in World Medical Research

DOI: 10.71204/s8ksf005

Authors: Wei Zhang, Guibao Li, Jingjing Yuan

Institutions: China Academy of Chinese Medical Sciences, Beijing Language and Culture University, Beijing University of Chinese Medicine, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

Language: English

Topic: Asthma and respiratory diseases

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Natural Science Foundation of China, Beijing University of Chinese Medicine, Chinese Academy of Medical Sciences