Work

Three-month functional outcomes of acute ischemic stroke in patients with chronic renal function impairment

Year: 2025

Type: article

Abstract: BACKGROUND: Chronic renal function impairment (RFI) increases the risk of acute ischemic stroke (AIS), greater stroke severity, and post-stroke disability and mortality. OBJECTIVE: We aimed to assess the three-month functional outcomes of AIS in patients with chronic RFI. METHODS: In this prospective study, stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS), and functional outcomes were assessed using the modified Rankin Scale (mRS). Outcomes were analyzed based on estimated glomerular filtration rate (eGFR). RESULTS: Among the 205 patients included (median age: 70 years, IQR: 61-82), 123 (60%) were male. Patients with lower eGFR had higher NIHSS scores (more severe strokes) and higher mRS scores at both baseline and three months (poorer functional outcomes). Based on a logistic regression model adjusted for confounding factors, higher eGFR was significantly associated with good three-month functional outcomes (adjusted OR = 2.634, 95% CI [1.207, 5.748], p = 0.015). CONCLUSIONS: Chronic RFI is associated with more severe strokes and poorer baseline and three-month functional outcomes after AIS. Future research should explore targeted management strategies to improve post-stroke recovery in this population.

Source: PLoS ONE

DOI: 10.1371/journal.pone.0323995

Authors: Dina Hemmati, Negin Eissazade, Shayan Eghdami, Zahra Mirzaasgari, Atefeh Amouzegar

Institutions: Iran University of Medical Sciences, Institute for Cognitive Science Studies, Tehran University of Medical Sciences

Language: English

Topic: Acute Ischemic Stroke Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,382