Year: 2025
Type: article
Abstract: The multicomponent Hosomi-Sakurai reaction, which gives homoallyl ethers from aldehydes, trimethylsilyl ethers and allyltrimethylsilane, was thoroughly studied using a bio-based aldehyde (protected 5-(hydroxymethyl)tetrahydrofuran-2-carboxyaldehyde) along with trimethylsilyl ethers derived from a variety of (mainly bio-based) alcohols. For comparison, a reactive aromatic aldehyde was also employed. These studies helped to identify the optimal conditions for each aldehyde and provided insight into the scope and limitations of this relatively underexplored multicomponent reaction, one of the few that can incorporate alcohols as diversity inputs.
Source: RSC Advances
DOI: 10.1039/d5ra03165f
Institutions: University of Genoa, Universidad de Valladolid
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,042
Awards: G2899963956, G364702999
OpenAlex ID: W4410863989