Work

Successive paired electrochemical late-stage modification of niclosamide a common anthelmintic drug. A green protocol for the synthesis of new drug-like molecules

Year: 2025

Type: article

Abstract: -(2-chloro-4-(phenylsulfonamido)phenyl)-2-hydroxy benzamide) after reduction and oxidation steps and reaction with the nucleophile. In the synthesized niclosamide analogs, a sulfonamide moiety is attached to the drug molecule. This work presents a green method for the synthesis of new niclosamide analogs without the need for catalysts, reductants or oxidants under mild conditions in a one-pot process.

Source: RSC Advances

DOI: 10.1039/d5ra02025e

Authors: Haniya Rezaei, Davood Nematollahi, Niloofar Mohamadighader, Farideh Lotfipour

Institution: Bu-Ali Sina University

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funder: Bu-Ali Sina University