Work

The effect of body mass index and total cholesterol levels on histopathological grading in breast cancer patients

Year: 2025

Type: article

Abstract: Background: Breast cancer is the most common cancer between females globally with many involving risk factors. There are increasing evidences about the role of obesity, which is usually assessed using body mass index (BMI), and hypercholesterolemia in breast cancer development through different mechanisms including the interplay with the immune response. The histopathological grading, which reflects the degree of differentiation, could be used to determine the aggressiveness of breast cancer. Limited studies assessed the correlation between the previous factors and histopathological grading in breast cancer patients and they concluded controversial results. Objective: We aimed to investigate the correlation of BMI and total cholesterol levels with histopathological grading in breast cancer patients with regard to menopausal status. Methods: Total cholesterol was measured using Qimica kit/Spain and data were analyzed using suitable statistical tests. P-value<0.05 was considered as statistically significant. Results: We found a significant relationship between BMI and tumor grading (P = 0.008). The correlation was observed in postmenopausal patients (P = 0.01) with no correlation in premenopausal patients (P = 0.32). Also, there was a significant correlation between total cholesterol and tumor grading (P = 0.003) only in postmenopausal patients (P = 0.011) with no correlation in premenopausal patients (P = 0.32). Conclusions: There is a significant relationship of histopathological grading with both BMI and total cholesterol levels in postmenopausal breast cancer patients. Further studies with larger samples are needed to evaluate the role of those factors in breast cancer progression and aggressiveness and their effects on immunotherapy tolerance and response.

Source: Annals of Medicine and Surgery

DOI: 10.1097/ms9.0000000000003371

Authors: Razan Hasan, Nader Abdalla, Maram Bilal

Institution: Latakia University

Language: English

Topic: Cancer Risks and Factors

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,850