The Role of Biomarkers in Predicting Cardiovascular Events in Autoimmune Diseases: Insights into Early Detection and Risk Stratification
Year: 2025
Type: article
Abstract: Autoimmune diseases (AIDs) are characterized by chronic inflammation and immune dysregulation, significantly increasing the risk of cardiovascular events (CVE). The identification and utilization of reliable biomarkers to predict CVE in patients with AIDs hold promise for improving early detection, risk stratification, and targeted intervention strategies. This article explores the current evidence supporting the role of biomarkers, including inflammatory mediators, endothelial dysfunction markers, autoantibodies, and novel genomic and proteomic signatures. Additionally, we discuss their clinical applicability, limitations, and integration into routine practice. Understanding the interplay between biomarkers and the pathophysiological mechanisms underlying cardiovascular complications in AIDs may pave the way for precision medicine approaches, optimizing outcomes in this vulnerable population.
Authors: Universidad Autonoma de Sinaloa. Sinaloa, México., Joshua Sanchez Felix, Donaldo Emiliano Silva López, Tecnológico de Monterrey Campus Monterrey. Monterrey, Nuevo Leon, Mexico., Sandra Valeria Zúñiga Torres, Benemérita Universidad Autónoma de Aguascalientes. Aguascalientes, Mexico., Angel Augusto Ornelas Guzmán, Universidad de Guanajuato. Guanajuato, Mexico., Luis Enrique Pacheco Moncada, Universidad Autonoma de Queretaro. Queretaro, Mexico., Walter Ivan Abitia Amarillas, Universidad Autonoma de Sinaloa. Sinaloa, México.
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4410864242