Year: 2025
Type: article
Abstract: The main cause in anovulatory infertility is PCOS, that affects 7–15% in women who are of reproductive age. Infertility impacts about 15% of couples and requires thorough evaluation, including history, physical, gynaecological, and endocrine assessments. The treatment of choice for PCOS-related infertility is clomiphene citrate. If it is ineffective, low- dose FSH stimulation is used to avoid problems such ovarian hyperstimulation and repeated pregnancies. Inhibitors of aromatase are new substitutes. Ovulation is improved by weight loss as well as insulin-sensitizing medications like metformin, though metformin is not advised unless metabolic issues are present. Myoinositol is a newer option under investigation. When medications fail, surgical methods such as laparoscopic ovarian drilling or transvaginal hydro laparoscopy are considered, particularly effective in lean women with high LH. IVF and in vitro maturation, which have outstanding success rates, are third-line choices. With current therapies, most women with PCOS-related infertility can achieve ovulation and pregnancy.
Author: Supriya Kumari
Institution: Lovely Professional University
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4410864321