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Author response: Mutations that prevent phosphorylation of the BMP4 prodomain impair proteolytic maturation of homodimers leading to lethality in mice

Year: 2025
Type: peer-review
Abstract: This fundamental work presents two clinically relevant BMP4 mutations that contribute to vertebrate development.The compelling evidence, both from wet lab and AI generated predictions, supports that the site-specific cleavage at the BMP4 pro-domain precisely regulates its function and provides mechanistic insight how homodimers and heterodimers behave differently.The work will be of broad interest to researchers working on growth factor signaling mechanisms and vertebrate development.
Source: eLife
DOI: 10.7554/elife.105018.4.sa4
Authors: Hyung-Seok Kim, Mary L Sanchez, Joshua Silva, Heidi L Schubert, Rebecca Dennis, Christopher P Hill, Jan L Christian
Institution: University of Utah
Language: English
Open Access status: gold
Estimated APC paid: $2,500
Funders: Huntsman Cancer Foundation, National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development
OpenAlex ID: W4410865473
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