Year: 2025
Type: article
Abstract: In this study, we demonstrate an effective method for the direct conversion of alkane chemical feedstocks to valuable oxime‐ethers through the functionalization of unpolarized C(sp3)─H bonds using light‐induced HAT‐catalysis. The process operates at room temperature, utilizing low catalyst loading (ppm level) and a reduced substrate‐to‐reagent ratio. Notably, the reaction can also be performed in sunlight, which makes the process further attractive toward sustainable synthesis of functionalized oxime‐ethers. The process displays a broad substrate scope, rendering desired products with up to 90% yields. The reaction is shown to be scalable. Through a series of mechanistic control studies, a radical reaction pathway featuring HAT‐induced C─H functionalization is implicated in the process.
Source: Chemistry - An Asian Journal
Authors: Jayanta Dey, Nayan Banerjee, Joyram Guin
Institution: Indian Association for the Cultivation of Science
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Award: G8694096663
OpenAlex ID: W4410865693