Year: 2025
Type: article
Abstract: Combining optical tweezers with fluorescence microscopy is a powerful tool for single-cell analysis, playing a pivotal role in disease diagnosis, cell sorting, and the investigation of cellular dynamics. However, fluorescence detection faces challenges such as blinking, photobleaching and autofluorescence in biotissues. To address these limitations, we developed a magnetic detection strategy by integrating quantum magnetometry using nitrogen-vacancy centers into optical tweezers, demonstrating precise trapping and manipulation of individual cells in microfluidic environment. We detected a magnetic signal of 89 μT from a single cell labeled with magnetic nanoparticles, compared to a noise floor of 3.9 μT observed in unlabeled cells. This platform provides a promising approach for high-precision single-cell analysis and holds significant potential for probing cellular activities within biological microenvironments.
Source: Chinese Physics B
Authors: Jun 俊 Yin 殷, Sanyou 三友 Chen 陈, Yihao 一皓 Yan 燕, Mengqi 孟祺 Wang 王, Ya 亚 Wang 王, Yiheng 毅恒 Lin 林, Qi 琪 Zhang 张, Fazhan 发展 Shi 石
Language: English
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4410865715