Work

A New Approach to Refine Genetic Predictors of Dietary Traits for Use in Mendelian Randomization

Year: 2025

Type: article

Abstract: Objectives: While Mendelian Randomization (MR) may help infer causal diet-disease links, many diet-related genetic variants (dGVs) are invalid to use in MR, as they violate a core assumption that they have no effect on diet-disease confounders (i.e., pleiotropy). We aimed to develop an approach to refine dGVs to those with

Source: Current Developments in Nutrition

DOI: 10.1016/j.cdnut.2025.107303

Authors: Julie E Gervis, Kristen J Sutton, Sara J Cromer, Miriam Udler, Joanne B Cole, Kenneth E Westerman

Institutions: Massachusetts General Hospital, University of Colorado Anschutz

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: gold

Estimated APC paid: $5,000