Serum Lactate Levels and Kinetics Predict Citrate Accumulation in Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy
Year: 2025
Type: article
Abstract: Regional citrate anticoagulation (RCA) is an established method of anticoagulation for continuous renal replacement therapy (CRRT). Citrate accumulation (CA) is one important complication for RCA-CRRT, especially amongst patients with liver failure or profound hypoxaemia. Accurate diagnosis and prediction of CA remains challenging, where existing means are often limited by their inconvenience, costs and availability. 1,2. Lactate is commonly measured and relatively low-cost laboratory test in the intensive care unit (ICU) setting, and here we reported the follow-up analyses of our previous multi-centre prospective study to determine the clinical utility of serum lactate for monitoring and predicting CA in RCA-CRRT 3.
Source: Kidney International Reports
Authors: Harmony Hau Man To, Arthur Ming Chit Kwan, Natalie Yat Yee Leung, Felix Chi Kin Wong, Wai Ming Chan, Chun Wai Ngai, Alfred Sai Kuen Wong, Polly Nga Wing Tsai, Tammy Sin Kwan Ma, Irene Yam, Pauline Yeung Ng, Desmond Yat Hin Yap
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,800
OpenAlex ID: W4410870894