Work

Clinical Implications of Striated Nephrogram in Patients Receiving Immune Checkpoint Inhibitors for Cancer

Year: 2025

Type: article

Abstract: Acute interstitial nephritis (AIN) is a common side effect of immune checkpoint inhibitor (ICI) therapy and develops in 2-5% of patients.1,2 Prompt recognition and differentiation of ICI-AIN from other causes of AKI are crucial for continuing ICIs.3 ICI-AIN is difficult to diagnose without a kidney biopsy, and there is an unmet need for non-invasive diagnostic markers.1 Recent studies suggest that cross-sectional imaging findings may be abnormal in patients with ICI-AIN.4,5,6 In our clinical experience, patients receiving ICIs may develop a ‘striated nephrogram’ (alternating bands of high and low contrast attenuation extending through corticomedullary layers of the kidney) on contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) studies performed as part of routine cancer surveillance (Figure 1).

Source: Kidney Medicine

DOI: 10.1016/j.xkme.2025.101038

Authors: Daiana Moreno, Paul E. Hanna, Kavita Mistry, Pedram Heidari, Meghan E. Sise, Harish Seethapathy

Institutions: Massachusetts General Hospital, Medical College of Wisconsin, Beth Israel Deaconess Medical Center

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,590