Work

The mechanism of nitrogenase: formation and release of the second NH 3 and completion of the cycle

Year: 2025

Type: article

Abstract: and its subsequent dissociation. The steps regenerating the resting state and completing the mechanism cycle are described. All steps in this third and final phase of the mechanism are thermodynamically and kinetically feasible. Atom S2B of FeMo-co, whose retention during enzyme turnover is experimentally controversial, remains intact as a bridge between Fe2 and Fe6 and is an essential H transfer agent in the proposed mechanism. The architecture of the active site and its surrounds that promote the chemical choreography of nitrogenase in its performance space are outlined, and key features and principles of the proposed complete mechanism are summarised.

Source: Dalton Transactions

DOI: 10.1039/d5dt00658a

Author: Ian Dance

Institution: UNSW Sydney

Language: English

Topic: Metalloenzymes and iron-sulfur proteins

Subfield: Renewable Energy, Sustainability and the Environment

Field: Energy

Domain: Physical Sciences

Open Access status: hybrid

Funders: National Computational Infrastructure, Australian Government, University of New South Wales, National Cancer Institute

OpenAlex ID: W4410875485

FWCI: 0.982

Cites: 114

Cited by: 7

Related to: 10