Work

X-ray fluorescence microscopy and X-ray absorption spectroscopy reveal the stability of the plecstatin-1 scaffold in biological model systems: comparison of Ru, Os and Ir analogues

Year: 2025

Type: article

Abstract: -cym, and the ancillary pca ligand, remain coordinated after incubation of plecstatin-1 in cell media (in the presence or absence of foetal bovine serum), or, in whole human blood, with the likely ligand substitution of the chlorido ligand for a thiol when available. The apparent stability of the complex scaffold to challenge from a wide variety of biological ligands can be used to rationalise the similar cell targeting behaviour of the Ru, Os and Ir complexes.

Source: Chemical Science

DOI: 10.1039/d5sc02925b

Authors: James H. Lovett, Barry P. Lai, Hugh O. Bloomfield, Ani T. Baker, Matthew P. Sullivan, Christian G. Hartinger, Hugh H. Harris

Institutions: The University of Adelaide, Argonne National Laboratory, University of Auckland

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: diamond

Funders: U.S. Department of Energy, Australian Nuclear Science and Technology Organisation, Australian Synchrotron, University of Auckland, Office of Science, Australian Research Council, Argonne National Laboratory

Awards: G102163711, G107546177, G1313983767, Visualising molecular level detail in single cells and intact tissues, G1664757510, G2287611682, G262962599, G3075337988, G498139845, G6848031779, G6918803902, G969889393, G993149817

OpenAlex ID: W4410875942

FWCI: 1.862

Cites: 66

Cited by: 5

Related to: 10