Progression of Atherosclerosis and Left Ventricular Dysfunction in High-Risk Young Women With and Without Polycystic Ovary Syndrome
Year: 2025
Type: article
Abstract: CVD) risk.We have shown that high-risk young adolescents and women with and without PCOS exhibit atherogenic dyslipidemia and atherosclerotic CVD (ACVD), and impaired cardiac function, compared with healthy-weight control participants.The aim of this study was to determine the natural history of atherogenic dyslipidemia, carotid intimal medial thickness (cIMT), and cardiac function in young women with and without PCOS.METHODS: Heart Health PCOS-Together (n ¼ 80, Canadian) and Androgens and Insulin Resistance study data (n ¼ 88; AIRS Children's Hospital, CO) were combined and age-and BMI-matched in women aged 12-45 years with and without PCOS.Two-dimensional and 3D echocardiography were used to determine carotid intimal medial thickness (cIMT) and cardiac function indices.RESULTS: cIMT, and cardiac left ventricular (LV) mass and wall thickness tended to be higher in PCOS and non-PCOS control participants in all age groups, and increased by 10%-20% at 30-45 years, compared with healthy-weight control participants.Cardiac E/A ratio was lower in PCOS and non-PCOS control participants in all age groups, and declined in those with PCOS at 30-45 years.LV ejection fraction was lower in PCOS at 20-29 and 30-45 years, and LV global longitudinal strain was impaired in PCOS and non-PCOS control participants at 30-45 years.CONCLUSIONS: The natural history and progression of ACVD and cardiac dysfunction provides evidence of premature development of CVD in high-risk young women, and this is exacerbated in those with PCOS.Recommendations for early screening to raise awareness for prevention of CVD in highrisk young women with and without PCOS is warranted.
Source: CJC Open
Authors: X. Wu, M. Ghosh M, P. Raggi, H. Becher, J. Windram, D. Vine
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,590
OpenAlex ID: W4410876314