Work

Sex-Specific Differences in Gestational Diabetes Mellitus-Induced Cardiac Hypertrophy and Altered Mitochondrial Protein Acetylation in the Offspring Heart and the Protective Role of SIRT3

Year: 2025

Type: article

Abstract: Gestational diabetes mellitus (GDM) increases risk of cardiovascular disease in offspring later in life, yet mechanisms, particularly sex-specific differences, remain unclear. GDM induces abhorrent protein acetylation in offspring cardiac mitochondria, partially due to reduced expression of deacetylase proteins, such as Sirtuin-3 (SIRT3). Protein acetylation is a major regulatory mechanism of metabolic enzymes in cardiac mitochondria. We hypothesize that increasing cardiac SIRT3 in offspring protects from GDM-induced cardiac dysfunction.

Source: CJC Open

DOI: 10.1016/j.cjco.2025.04.026

Authors: C. Menzies, M. Tomczyk, B. Xiang, S. Kereliuk, R. Leduc, V. Dolinsky

Language: English

Topic: Gestational Diabetes Research and Management

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,590

OpenAlex ID: W4410876389

FWCI:

Cites:

Cited by:

Related to: 10