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Treatment of Autoimmune Enteropathy With Vedolizumab

Year: 2025

Type: article

Abstract: Autoimmune enteropathy (AIE) is a rare condition characterized by immune-mediated villous atrophy with associated chronic diarrhea. In this case, a 34-year-old man with AIE was treated with vedolizumab, an anti-ɑ4b7 integrin that inhibits intestinal lymphocyte trafficking, after initial treatments with prednisone, open-capsule budesonide, azathioprine, infliximab, and adalimumab showed minimal response. Vedolizumab resulted in moderate symptomatic and histological improvement but was discontinued due to possible drug-induced liver injury. This case suggests the potential therapeutic efficacy of vedolizumab in treating AIE, though more research is needed.

Source: ACG Case Reports Journal

DOI: 10.14309/crj.0000000000001716

Authors: Tara Alleyasin, Evan Wilder, Warren Reidel, Emma Du, Quan M. Nhu

Institutions: Scripps Health, Scripps Green Hospital, Scripps Clinic, Scripps Research Institute

Language: English

Topic: Inflammatory Bowel Disease

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4410892256

FWCI:

Cites: 10

Cited by:

Related to: 10