Preparation and Properties of Calcium Peroxide/Poly(ethylene glycol)@Silica Nanoparticles with Controlled Oxygen-Generating Behaviors
Year: 2025
Type: article
Abstract: The hypoxic microenvironment is the main challenge for the repair of damaged tissue, and oxygen supply is an effective means of alleviating hypoxia. In this study, a series of core–shell-structured calcium peroxide/poly(ethylene glycol)@silica (CPO@SiO2) nanoparticles are prepared to generate oxygen steadily. The size of the CPO@SiO2 nanoparticles ranges from 205 to 302 nm, with a narrow polydispersity index (PDI). In this system, the nano CPO core acts as the oxygen source to improve hypoxia, while the SiO2 shell layer serves as the physical barrier to control the oxygen-generating rate and improve biocompatibility. The results suggest that the thickness of the SiO2 shell layer can be modulated by adjusting the amount of tetraethyl orthosilicate (TEOS). The prepared CPO@SiO2 nanoparticles show a controlled oxygen-generating rate. Moreover, compared with CPO, the CPO@SiO2 nanoparticles have good biocompatibility. To assess the modulating effects for the hypoxic microenvironment, L929 cells are co-cultured with CPO@ SiO2 nanoparticles under hypoxia. The results suggest that the CPO@ SiO2 nanoparticles can support the cell survival under hypoxia. Moreover, they can effectively decrease oxidative stress damage and reduce the levels of expression of hypoxia-induced superoxide dismutase (SOD) and malondialdehyde (MDA). Therefore, the prepared CPO@ SiO2 nanoparticles with controlled oxygen-generating properties could be a promising candidate for repairing damaged tissue.
Source: Materials
DOI: 10.3390/ma18112568
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,137
Awards: G300091857, G4435257474
OpenAlex ID: W4410894527