Work

Cross-linking teichoic acids by click chemistry prevents bacterial cell growth

Year: 2025

Type: article

Abstract: . Unlike conventional cell-wall targeting antibiotics, which inhibit the natural cross-linking of peptidoglycan, we introduce artificial cross-links in the other main component of the Gram-positive cell wall, the teichoic acids, and show that it leads to impaired cell growth.

Source: Chemical Communications

DOI: 10.1039/d5cc02577j

Authors: Morgane Baudoin, Anne Chouquet, Célia Boyat, Cédric Laguri, André Zapun, Basile Pérès, Cecile Morlot, Yung-Sing Wong, Claire Durmort

Institutions: Centre National de la Recherche Scientifique, Département de Pharmacochimie Moléculaire, Université Grenoble Alpes, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Institut de Biologie Structurale

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: LABoratoires d’EXcellence ARCANE, Agence Nationale de la Recherche, Centre National de la Recherche Scientifique, French Infrastructure for Integrated Structural Biology

Awards: G1064512522, CBH-EUR-GS, Unraveling the dynamics of bacterial cell wall synthesis and maturation at the nanoscale, G2389725886, G256544642, Looking for proteins regulating Peptidoglycan synthases, G2659019386, G3010527862, G4399195447, Cell wall “clicking” as a selective weapon against Streptococcus pneumoniae, G678225801, G6803667113, G7240651115, G7819545319, G8548513469, Infrastructure Française pour la Biologie Structurale Intégrée

OpenAlex ID: W4410894571

FWCI:

Cites: 20

Cited by:

Related to: 10