Comparative Analysis of Cold Versus Thermal Dissection in Nerve-Sparing Robot-Assisted Radical Prostatectomy
Year: 2025
Type: article
Abstract: Background: Cold dissection (CD) during nerve-sparing robot-assisted radical prostatectomy (nsRARP) in patients with prostate cancer has been proposed to improve functional outcomes by reducing the thermal damage to neurovascular bundles (NVBs). This study compares the impact of CD versus thermal dissection (TD) on postoperative early continence and erectile function recovery. Methods: A prospective comparative analysis was conducted on patients undergoing nsRARP, comparing CD and TD techniques. Continence was assessed at 15, 30, and 90 days, while erectile function was evaluated at 30, 90, and 180 days using IIEF-5 scores. Logistic and linear regression analyses were performed to identify predictors of functional recovery. Results: CD significantly improved early continence at 15 and 30 days (p < 0.05), although the difference diminished by 90 days. Erectile function recovery was consistently higher in the CD group at all time points (p < 0.01). Age negatively impacted continence and erectile function recovery, while preoperative IIEF-5 scores were strong predictors of erectile function. Prostate volume, BMI, and metabolic syndrome showed no significant influence on outcomes. Conclusions: CD enhances early continence and erectile function recovery following nsRARP by preserving NVBs and minimizing thermal damage. This technique offers a valuable approach to improving patient functional outcomes. Further studies are required to validate its long-term benefits.
Source: Cancers
Authors: Andrea Fuschi, Manfredi Bruno Sequi, Yazan Al Salhi, Paolo Pietro Suraci, Fabio Maria Valenzi, Onofrio Antonio Rera, Alice Antonioni, Damiano Graziani, Giorgio Martino, Giuseppe Candita, Filippo Gianfrancesco, Paolo Benanti, Luca Erra, Giovanni Di Gregorio, Riccardo Lombardo, Anastasios D. Asimakopoulos, Cosimo De Nunzio, Felice Crocetto, Matteo Pacini, Eleonora Sollazzi, Alessandro Zucchi, Antonio Carbone, Antonio Luigi Pastore
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
OpenAlex ID: W4410896473