Work

Rational Design of Novel Quinazolinone–Pyrrolodihydropyrrolone Analogs as PIM/HDAC Dual-Target Inhibitors for the Treatment of Acute Myelocytic Leukemia

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c00040

Authors: Yabing Xin, Can Xiao, Nan Wang, Huidan Wu, Wenjing Kang, Xuetao Chen, Chihong Liu, Qidong You, Zhengyu Jiang, Xiaoke Guo

Institutions: China Pharmaceutical University, State Key Laboratory of Natural Medicine

Language: English

Topic: Histone Deacetylase Inhibitors Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Fundamental Research Funds for the Central Universities, Natural Science Foundation of Jiangsu Province for Distinguished Young Scholars

Awards: G2672293405, G278728124, G3797499583, G6955172286

OpenAlex ID: W4410898934

FWCI: 2.293

Cites: 68

Cited by: 9

Related to: 10