Work

Temperature alters the inotropic and chronotropic effect of D1-dopamine receptor stimulation in the mammalian atrium

Year: 2025

Type: article

Abstract: We studied how hypothermia and hyperthermia may change the efficacy and/or potency of dopamine to augment the force of contraction in atria of mice with cardiac overexpression of the human D 1 -dopamine receptor (D 1 -TG). We measured the force of contraction on paced (1 Hz) left atria and spontaneously beating right atria of these D 1 -TG mice in vitro. The intrinsic heart beat in the right atria from D 1 -TG mice lowered when we reduced the temperature (24 °C, hypothermia) and elevated when we raised the temperature (42 °C, hyperthermia) in the organ baths. In addition, the efficacy of dopamine (0.001–100 µM) to augment the force of contraction was diminished in the left and right D 1 -TG mouse atrial preparations under 24 °C and 42 °C compared to 37 °C in the organ baths. Likewise, the rise in force after dopamine was diminished at 24 °C and 42 °C compared to 37 °C in paced human atrial preparations (HAP) obtained from patients who underwent surgery. In conclusion, the inotropic effects of dopamine in D 1 -TG mice and in human atrial preparation via D 1 -dopamine receptors, but also the effects of dopamine in D 1 -TG mice on the heartbeat, change with ambient temperature.

Source: Naunyn-Schmiedeberg s Archives of Pharmacology

DOI: 10.1007/s00210-025-04313-6

Authors: Peter Grundig, Thanh Hoai Pham, Britt Hofmann, Joachim Neumann, Ulrich Gergs

Institutions: Martin Luther University Halle-Wittenberg, University Hospital in Halle

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,790