Work

A retrospective study on the impact of the timing of diabetes diagnosis on maternal and fetal outcomes

Year: 2025

Type: article

Abstract: PURPOSE: This study aimed to evaluate the impact of the timing of diabetes diagnosis on maternal and fetal outcomes. METHODS: The data were collected from pregnant women diagnosed with pregestational diabetes mellitus (PGDM) who were hospitalized at Dongguan People's Hospital between June 2016 and December 2023. Based on the timing of diagnosis, women were categorized into two groups: those diagnosed before pregnancy and those diagnosed during pregnancy. General clinical characteristics, glycemic control, pregnancy complications, and maternal and fetal outcomes were compared between the two groups to assess the influence of diagnosis timing on pregnancy outcomes. RESULTS: Between 2016 and 2023, a total of 415 pregnant women with PGDM were included in this study. Among them, 242 (58.31%) were diagnosed before pregnancy, while 173 (41.69%) were diagnosed during pregnancy, resulting in a preconception diabetes awareness rate of 58.31%. Education level was significantly associated with the timing of diabetes diagnosis (P = 0.002). In addition, women diagnosed during pregnancy had significantly higher HbA1c levels before delivery when compared with those diagnosed before pregnancy (6.70% vs. 6.20%, P < 0.001), indicating more severe glycemic dysregulation. Consequently, this group also exhibited a higher rate of diabetes-related hospitalizations during pregnancy (42.77% vs. 22.73%, P < 0.001) and an increased risk of macrosomia (20.23% vs. 10.74%, P = 0.007). CONCLUSION: Pregnant women diagnosed with diabetes during pregnancy exhibited more severe perinatal glucose metabolism disorders and a higher rate of macrosomia. Early diagnosis and management of diabetes-especially before conception-helped improve perinatal glycemic control, potentially reducing healthcare burdens and the incidence of macrosomia.

Source: Archives of Gynecology and Obstetrics

DOI: 10.1007/s00404-025-08047-x

Authors: Kaiyan Zhou, Wenting Chen, Shuzhen Wu, Lin Li, Yuting Xiang, Zhongjun Li

Institutions: Guangdong Medical College, Dongguan People’s Hospital, Southern Medical University

Language: English

Topic: Gestational Diabetes Research and Management

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,590