Year: 2025
Type: article
Abstract: 神经胶质瘤是一类发源于中枢神经系统的恶性肿瘤，起源于神经胶质细胞。它们在神经系统中具有严重的侵袭性和生存率低的特点。尽管目前的治疗方法包括手术切除、放疗和化疗，但这些方法往往不能带来理想的治疗效果，特别是对于高度恶性的胶质母细胞瘤。因此，寻找新的治疗靶点和策略对于改善脑胶质瘤患者的预后至关重要。JAK/STAT信号通路是一种关键的细胞信号传导通路，调控许多生理过程，如细胞生长、分化、凋亡和免疫反应等。近年来，研究者们发现JAK/STAT信号通路在神经胶质瘤的发生、发展和耐药性等方面具有重要作用。因此，深入探讨JAK/STAT信号通路与神经胶质瘤之间的关系对于理解脑胶质瘤的发病机制、识别新的治疗靶点和开发新型药物具有重要意义。本综述旨在总结近年来关于JAK/STAT信号通路在神经胶质瘤中的研究进展，包括信号通路异常激活的分子机制、信号通路在胶质瘤生物学行为中的作用以及针对JAK/STAT信号通路的治疗策略。Gliomas are a class of malignant tumors originating from the central nervous system, specifically from neuroglial cells. They are characterized by severe invasiveness in the nervous system and low survival rates. Although current treatment methods include surgical resection, radiation, and chemotherapy, these often do not yield satisfactory results, particularly in the case of highly malignant glioblastomas. Therefore, identifying new therapeutic targets and strategies is crucial for improving the prognosis of patients with brain gliomas. The JAK/STAT signaling pathway is a key cellular signaling pathway that regulates numerous physiological processes, such as cell growth, differentiation, apoptosis, and immune responses. Recently, researchers have found that the JAK/STAT signaling pathway plays an important role in the pathogenesis, progression, and drug resistance of gliomas. Therefore, a thorough exploration of the relationship between the JAK/STAT signaling pathway and gliomas is significant for understanding the pathogenesis of brain gliomas, identifying new therapeutic targets, and developing novel drugs. This review aims to summarize recent advances in research on the JAK/STAT signaling pathway in gliomas, including the molecular mechanisms of abnormal pathway activation, the role of this pathway in glioma biology, and therapeutic strategies targeting the JAK/STAT signaling pathway.
Source: Advances in Clinical Medicine
Author: 奇 毛
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4410901593