A Study on Near-Infrared Spectroscopy (NIRS) Brain Functional Imaging in Patients with Somatic Symptom Disorder during Verbal Fluency Tasks
Year: 2025
Type: article
Study design: Observational Study
Abstract: 目的：运用fNIRS检测技术，比较躯体痛苦障碍(Bodily Distress Disorder, BDD)患者和健康对照组(Healthy Control Group, HC)患者，在基于言语流畅性任务(Verbal Fluency Task, VFT)期间前额叶激活是否存在差异，以及基于ROI感兴趣区，比较BDD患者与压力知觉是否相关。方法：通过近红外光谱脑功能成像(functional near infrared spectroscopy, fNIRS)技术，比较14例BDD患者与20例HC患者，在VFT下前额叶氧合血红蛋白(oxyhemoglobin, Oxy-Hb)浓度变化以及基于感兴趣脑区与压力知觉的关系研究。结果：基于ROI感兴趣脑区分析发现VFT任务下，BDD组在背外侧前额叶皮质(Z = −2.62, P Z = −4.27, P r = −0.599, P r = −0.551, P Objective: To utilize functional near-infrared spectroscopy (fNIRS) technology to compare differences in prefrontal activation between patients with bodily distress disorder (BDD) and healthy control subjects (Healthy Control Group, HC) during the verbal fluency task (VFT), as well as to investigate the correlation between BDD and stress perception based on regions of interest (ROI). Methods: Through functional near-infrared spectroscopy (fNIRS) technology, we compared changes in oxyhemoglobin (Oxy-Hb) concentration in the prefrontal cortex of 14 BDD patients and 20 HC subjects during the VFT, and explored the relationship between brain regions of interest and stress perception. Results: ROI-based analysis revealed that during the VFT, the BDD group exhibited significantly smaller hemodynamic changes in the dorsolateral prefrontal cortex (Z = −2.62, P Z = −4.27, P r = −0.599, P r = −0.551, P < 0.05). Conclusion: Compared to HC subjects, BDD patients showed relatively reduced function in prefrontal cortical regions, specifically in the dorsolateral prefrontal cortex and the frontal pole region. This reduction in prefrontal cortical function is associated with heightened stress perception in individuals with BDD.
Source: Advances in Clinical Medicine
Author: 修文 应
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4410901668