Causal impact of genetically determined metabolites on kidney cancer and its subtypes: an integrated mendelian randomization and metabolomic study
Year: 2025
Type: article
Study design: Observational Study
Abstract: ). Metabolomic profiling of ccRCC tissues confirmed aberrant levels of seven metabolites, including elevated 2-hydroxyglutarate (fold change [FC] = 3.1, P = 0.001) and reduced citrate (FC = 0.4, P = 0.001), both associated with disease progression. In conclusion, this integrative study identified carnitine and trigonelline as potential contributors to RCC progression, while gamma-glutamylthreonine appears to be specifically involved in chRCC pathogenesis. Additionally, altered expression of sphingosine 1-phosphate, acetylcarnitine, gamma-glutamylglutamine, and N-acetylcytidine in ccRCC highlights key metabolic disruptions and underscores their potential as novel biomarkers and therapeutic targets in kidney cancer.
DOI: 10.62347/vuzh4644
Author: Zheng Wang
Institutions: Second Military Medical University, Changhai Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4410902164